Neurological complications are not usually considered among the most i
mportant complications that may appear after allogeneic bone marrow tr
ansplantation (BMT). We have analyzed the occurrence of neurological m
anifestations in 27 recipients of allogeneic BMT, Ten patients (37%) d
eveloped neurological symptoms, and 14 episodes were registered, The m
ost frequent manifestations were due to the use of cyclosporin A or pr
ednisone for prophylaxis or treatment of graft-versus-host disease (GV
HD), Cerebrovascular events (infarction or hemorrhage) and CNS infecti
ons were the most severe complications: they represented 26% of causes
of death in our series, In conclusion, neurological complications are
frequent in these patients, and represent an important cause of morbi
dity and mortality.