S. Gallacher et al., EVIDENCE FOR PRODUCTION OF PARALYTIC SHELLFISH TOXINS BY BACTERIA ASSOCIATED WITH ALEXANDRIUM SPP (DINOPHYTA) IN CULTURE, Applied and environmental microbiology, 63(1), 1997, pp. 239-245
A substantial proportion of bacteria from five Alexandrium cultures or
iginally isolated from various countries produced sodium channel block
ing (SCB) toxins, as ascertained by mouse neuroblastoma assay. The qua
ntities of SCB toxins produced by bacteria and dinoflagellates were no
ted, and the limitations in comparing the toxicities of these two orga
nisms are discussed. The chemical nature of the SCB toxins in selected
bacterial isolates was determined as paralytic shellfish toxins by pr
e- and postcolumn high-performance liquid chromatography, capillary el
ectrophoresis-mass spectrometry, and enzyme immunoassay.