A MODEL OF INFLUENZA-A DRIFT EVOLUTION

Authors
ANDREASEN V LEVIN S LIN J
Citation
V. Andreasen et al., A MODEL OF INFLUENZA-A DRIFT EVOLUTION, Zeitschrift fur angewandte Mathematik und Mechanik, 76, 1996, pp. 421-424
Citations number
20
Categorie Soggetti
Mathematics,"Mathematical Method, Physical Science",Mechanics,Mathematics
Journal title
Zeitschrift fur angewandte Mathematik und Mechanik → ACNP
ISSN journal
00442267
Volume
76
Year of publication
1996
Supplement
2
Pages
421 - 424
Database
ISI
SICI code
0044-2267(1996)76:<421:AMOIDE>2.0.ZU;2-K
Abstract
The antigenic properties of the influenza A virus drift slowly due to point mutations in the viral genome. The drift is enhanced by the part ial immunity of the host population to the new viral strains. Assuming a one dimensional axis of antigenic types we develop a model for the drift and find that a traveling wave of disease prevalence move along the axis with a speed that depends on the immune surveillance in the p opulation.