RESPONSES OF CATECHOLAMINES, RENIN-ANGIOTENSIN SYSTEM, AND ATRIAL-NATRIURETIC-PEPTIDE TO EXERCISE IN UNTRAINED MEN AND WOMEN

1. Plasma norepinephrine (NE), epinephrine (E), renin activity (PRA), angiotensin TI (ATII), aldosterone (ALD), and atrial natriuretic pepti de (ANP) were measured in 20 male and 15 female subjects during submax imal treadmill test. 2. Exercise duration was not different between th e two groups (male vs. female: 13.4 +/- 0.8 min vs. 11.6 +/- 0.7 min, ns). Female subjects had higher heart rate during exercise, while syst olic blood pressure at peak exercise was higher in male subjects. 3. P lasma NE, E, ANP, and ATII responses were comparable between male and female subjects, but PRA both at rest and during exercise and ALD at r est were significantly higher in male subjects. 4. Cardiac responses t o submaximal exercise were different between male and female subjects, but neurohormonal responses were comparable between the two groups ex cept for the high PRA at rest and during exercise and high plasma ALD at rest in male subjects. Copyright (C) 1977 Elsevier Science Inc.