VOLATILE compounds in comets are the most pristine materials surviving
from the time of formation of the Solar System, and thus potentially
provide information about conditions that prevailed in the primitive s
olar nebula(1-3). Moreover, comets may have supplied a substantial fra
ction of the volatiles on the terrestrial planets, perhaps including o
rganic compounds that played a role in the origin of life on Earth(4-6
), Here we report the detection of hydrogen isocyanide (HNC) in comet
Hyakutake. The abundance of HNC relative to hydrogen cyanide (HCN) is
very similar to that observed in quiescent interstellar molecular clou
ds, and quite different from the equilibrium ratio expected in the out
ermost solar nebula, where comets are thought to form. Such a departur
e from equilibrium has long been considered a hallmark of gas-phase ch
emical processing in the interstellar medium(7), suggesting that inter
stellar gases have been incorporated into the comet's nucleus, perhaps
as ices frozen onto interstellar grains. If this interpretation is co
rrect, our results should provide constraints on the temperature of th
e solar nebula, and the subsequent chemical processes that occurred in
the region where comets formed.