INHIBITION OF PLATELET ACTIVATION BY MM-706, A STABLE CARBACYCLIN ANALOG, IN THE CONSCIOUS RAT

A new stable analog of carbacyclin, 15,16,17,18,19,20-hexanor-14-(1-hy droxycyclohexyl) carbacyclin, identified as MM-706, was investigated i n vivo in the conscious rat. MM-706 as single bolus (200 mu g/kg, equi valent to 546 nmol/kg) prevented the reduction of circulating platelet s induced by adenosine diphosphate (ADP) (1 mu mol/kg as IV bolus). 2. A similar effect on free platelet numbers also was observed with ilop rost (20 and 200 mu g/kg IV bolus). However, MM-706 did not induce any significant Variation of mean arterial blood pressure (MABP) or heart rate, unlike iloprost, which reduced MABP within 10 min of administra tion. 3. In conclusion, MM-706 is effective in interfering with in viv o platelet activation induced by ADP without influencing other cardiov ascular parameters, such as arterial pressure and heart rate. Copyrigh t (C) 1997 Elsevier Science Inc.