EFFECT OF TYB-2285 ON LUNG ANAPHYLAXIS IN ACTIVELY SENSITIZED RATS

1. We examined the effect of TYB-2285 on the acute phase and the late phase of lung anaphylaxis in rats. 2. TYB-2285 (3-30 mg/kg PO) inhibit ed antigen-induced bronchoconstriction and TxB(2) production during th e acute phase of lung anaphylaxis in a dose-dependent manner. 3. Ketot ifen fumarate (30 mg/kg PO) inhibted bronchoconstriction and TxB(2) pr oduction less potently than TYB-2285. 4. TYB-2285 (30 mg/kg PO) inhibi ted the accumulation of neutrophils during the late phase of lung anap hylaxis significantly without a significant change in total cells. 5. Hydrocortisone acetate (100 mg/kg PO) inhibited the accumulation of to tal cells as potent as neutrophils. Copyright (C) 1997 Elsevier Scienc e Inc.