The c-H-ras-1 gene of an B6C3F1 mouse was isolated and nucleotide sequ
ence determined. Our-study has revealed that this c-H-ras-l gene consi
sts of four exons, separated by three introns ranging in size from 150
to 649 bp. The coding parts of the sequence of mouse c-H-ras-l gene s
how no important differences as compared with those of the rat, hamste
r and human gene. More numerous changes were found in introns. The ide
ntity of mouse c-H-uas-l gene with rat,hamster and human ones at the n
ucleotide level is 86.40%, 80.04% and 67.87%, respectively. Comparison
of amino acids in protein sequence of c-H-ras gene of mouse, rat, ham
ster and human points to high degree of conservation of the gene.