HISTOPATHOLOGY OF BONE-MARROW AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR CHRONIC MYELOID-LEUKEMIA

The histopathology of bone marrow after allogeneic bone marrow transpl antation for chronic myeloid leukaemia (CML) was studied in 20 bone ma rrow biopsy specimens from 14 patients. Biopsies were performed at day 30 post-transplantion (5 biopsies), between day 90 and day 100 (14 bi opsies), and one year post-transplantation (1 biopsy). Eight biopsies taken at day 30 post-transplantation for lymphoproliferative disorder were studied as controls. Granulopoiesis was predominant in all day 30 bone marrows in patients treated for Chit. In 2 cases, rejection tons suspected because of marrow hypoplasia at day 30: one case developed acute leukaemia soon after persistant hypoplasia at day 90 while the e volution of the other case was good. Two day 30 biopsies showed granul ocytic hyperplasia but follow-up proved complete remission of CML. Thu s, in our series, early biopsies at day 30 did not have any prognostic value. Twelve cases at clay 90-100 showed little modifications, such as minor dyserythropoiesis and dysmegakaryopoiesis. One case showed gr anulocytic hyperplasia at day 100 but bone marrow was normal one year Inter and the patient in complete remission. The haematopoietic recons titution after allogeneic bone marrow transplantation may present a tr ansient granulocytic hyperplasia that must not be diagnosed as a persi stence of CML.