EVIDENCE THAT TOLC IS REQUIRED FOR FUNCTIONING OF THE MAR ACRAB EFFLUX PUMP OF ESCHERICHIA-COLI/

Authors
FRALICK JA
Citation
Ja. Fralick, EVIDENCE THAT TOLC IS REQUIRED FOR FUNCTIONING OF THE MAR ACRAB EFFLUX PUMP OF ESCHERICHIA-COLI/, Journal of bacteriology, 178(19), 1996, pp. 5803-5805
Citations number
38
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology → ACNP
ISSN journal
00219193
Volume
178
Issue
19
Year of publication
1996
Pages
5803 - 5805
Database
ISI
SICI code
0021-9193(1996)178:19<5803:ETTIRF>2.0.ZU;2-D
Abstract
A study examining the influence of TolC on AcrA, AcrR, and MarR1 mutan ts indicates that functional TolC is required for the operation of the AcrAB efflux system and for the expression of the Mar phenotype. That the effect of TolC on the AcrAB pump is not regulatory in nature is s hown by studies measuring the influence of a tolC::Tn10 insertion muta tion on the expression of an acrA::lacZ reporter fusion. These results are compatible with the hypothesis that TolC is a component of the Ac rAB efflux complex.