COMPARATIVE CLINICAL-STUDIES OF PLATELET CONCENTRATES - EFFECTS ON CLINICAL OUTCOME AND THE USE OF HEALTH-CARE RESOURCES

The Platelet Study Group are developing proposals to conduct a prospec tive randomised trial of different platelet products in the transfusio n support of patients with haematological malignancy. All patients wil l receive prestorage leucodepleted red cells and will be randomised to receive either multiple donor non-apheresis buffy coat platelets whic h are non-leucodepleted (BCP), single donor apheresis platelets non-le ucocyte depleted (SDP) or single donor apheresis platelets leucocyte d epleted (LD-SDP). All leucocyte depleted products will contain fewer t han 5 x 10(6) WBC/transfusion. The primary objective of the study is t o compare clinical efficacy, the incidence of adverse reactions treatm ent outcome and the use of healthcare resources. Copyright (C) 1996 Pu blished by Elsevier Science Ltd