EFFECT OF 6 MONTHS OF GROWTH-HORMONE THERAPY, FOLLOWED BY TREATMENT WITHDRAWAL IN SHORT CHILDREN WITH NORMAL QUANTITATIVE INDEXES OF GROWTH-HORMONE SECRETION

Authors
CHALEW SA PHILLIP M KOWARSKI A
Citation
Sa. Chalew et al., EFFECT OF 6 MONTHS OF GROWTH-HORMONE THERAPY, FOLLOWED BY TREATMENT WITHDRAWAL IN SHORT CHILDREN WITH NORMAL QUANTITATIVE INDEXES OF GROWTH-HORMONE SECRETION, The Journal of pediatrics, 129(3), 1996, pp. 456-458
Citations number
12
Categorie Soggetti
Pediatrics
Journal title
The Journal of pediatrics → ACNP
ISSN journal
00223476
Volume
129
Issue
3
Year of publication
1996
Pages
456 - 458
Database
ISI
SICI code
0022-3476(1996)129:3<456:EO6MOG>2.0.ZU;2-X
Abstract
Eight short patients with normal 24-hour integrated concentration of g rowth hormone by continuous withdrawal (IC-GH) received 6 months of GH therapy, followed by 6 months of GH therapy increased growth rate (+2 .9 cm/yr), repeated IC-GH (sixfold), and IGF-1 concentration (twofold) . Posttreatment growth reverted to the pretreatment rate. Thus increas ed growth rate and IGF-1 concentration is associated with supraphysiol ogic IC-GH after injection.