IN-VITRO ACTIVITIES OF 2 NOVEL OXAZOLIDINONES (U100592 AND U100766), A NEW FLUOROQUINOLONE (TROVAFLOXACIN), AND DALFOPRISTIN-QUINUPRISTIN AGAINST STAPHYLOCOCCUS-AUREUS AND STAPHYLOCOCCUS-EPIDERMIDIS

Authors
MULAZIMOGLU L DRENNING SD YU VL
Citation
L. Mulazimoglu et al., IN-VITRO ACTIVITIES OF 2 NOVEL OXAZOLIDINONES (U100592 AND U100766), A NEW FLUOROQUINOLONE (TROVAFLOXACIN), AND DALFOPRISTIN-QUINUPRISTIN AGAINST STAPHYLOCOCCUS-AUREUS AND STAPHYLOCOCCUS-EPIDERMIDIS, Antimicrobial agents and chemotherapy, 40(10), 1996, pp. 2428-2430
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
10
Year of publication
1996
Pages
2428 - 2430
Database
ISI
SICI code
0066-4804(1996)40:10<2428:IAO2NO>2.0.ZU;2-9
Abstract
Two oxazolidinones (U100592 and U100766), trovafloxacin, and a strepto gramin combination (dalfopristin-quinupristin) were highly active in v itro against Staphylococcus aureus and Staphylococcus epidermidis, inc luding methicillin-resistant strains. Trovafloxacin was more active th an ciprofloxacin. Time-kill synergy studies demonstrated indifference for the oxazolidinones combined with vancomycin and rifampin against m ethicillin-resistant staphylococci. Spontaneous resistance was observe d with all agents.