ADJUVANT CHEMOTHERAPY IN CANCER OF THE CO LON

the last decade, adjuvant chemotherapy has led to significant improvem ent in survival for large bowel cancer patients, The association of 5- FU plus levamisole was the first described and demonstrated its effica cy in stage Dukes C (T1,2,3,4 N1 MO) completely-resected adenocarcinom a. Recently, chemotherapy with 5-FU and folinic acid was recommended o n the basis of randomized trials, Advances in adjuvant chemotherapy ma y result in increasing 5-FU doses as described in metastatic colorecta l carcinomas, and in use of new drugs such as oxaliplatin or raltitrex ed, whose activity has been well-studied in Dukes D (M1) carcinomas, I mmunotherapy, intraperitoneal and intraportal infusion of chemotherapy are promising approaches but still in evaluation, The main difficulty for the future is to define the best therapeutic regimen in order to reach the highest improvement in survival.