DRUG-RELEASE FROM COMPRESSED EUDRAGIT RS 30D COATED BEADS

Tablets of different hardnesses and compositions were prepared with an original theophylline granulate previously coated with Eudragit RS 30 D. Dissolution studies of each tablet formulation were performed to ve rity any kinetic variation from the dissolution profile. This was obta ined by filling with the same coated granules in a hard gelatine capsu le. While the dissolution profile of the capsules possesses very good linearity, the tablet kinetics gradually deviate from this linearity w ith an increase in the percentage of the coated granules in the formul ation. Tablet hardness had only a marginal influence on this kinetic d eviation.