BODY-WEIGHT IN CHILDREN WITH TURNER SYNDROME TREATED WITH GROWTH-HORMONE

OBJECTIVE: As overweight is a major concern in many children with Turn er syndrome, we studied the effect of growth-promoting treatment with human growth hormone (hGH) on body weight indices. DESIGN: Longitudina l study of the effect of hGH on weight indices over time in a cohort o f Turner girls of different ages. SUBJECTS: An index group of 199 hGH treated girls and a reference group of 569 untreated girls. METHODS: T urner-specific weight-for-age, weight-for-height and body mass index-f or-age (BMI) values were computed. In order to take account of regress ion to the mean, we studied spontaneous changes of these variables in the reference group. References for spontaneous changes over 3, 6, 12 or 24 months were constructed. Observed changes in the index group wer e corrected by subtracting the expected spontaneous change. Corrected changes were compared between overweight, normal and underweight child ren. RESULTS: Treatment with hGH leads to a temporary decrease of weig ht indices during the first six months. This decreasing effect was not seen in overweight children. Treatment increases BMI in overweight ch ildren over 24 months, but not in normal or underweight children. BMI at start of hGH treatment did not modify long-term growth response. CO NCLUSION: hGH treatment does not help to improve BMI in Turner syndrom e children with a tendency to overweight.