LIPID CORRECTED PLASMA ALPHA-TOCOPHEROL VALUES ARE INVERSELY RELATED TO FASTING INSULINEMIA IN OBESE CHILDREN

Plasma concentrations of alpha-tocopherol and retinol were measured in 17 obese children (10 boys and 7 girls, age: 13.9 +/- 0.3 y, mean +/- s.e.m.) and related to anthropometric indices and fasting plasma insu lin concentrations. Body weight was 89.0 +/- 5.3 kg, relative body wei ght 165 +/- 6%, body fat content 38.9 +/- 1.2% and body mass index 32. 3 +/- 1.3 kg/m(2). Plasma alpha-tocopherol, retinol and insulin concen trations were 18.5 +/- 1.6 mu mol/l, 2.0 +/- 0.2 mu mol/l and 17.2 +/- 1.6 mU/l, respectively. Neither alpha-tocopherol nor retinol concentr ations were related to age. Plasma retinol concentrations were positiv ely correlated to weights (r = 0.60, P = 0.01) and heights (r = 0.65, P < 0.01), but not to body fat contents. In contrast, plasma alpha-toc opherol concentrations were not related to weights and heights, but a significant inverse relation was seen to body fat contents (r = -0.49, P = 0.04). Pasting plasma insulin concentrations did not correlate wi th plasma retinol values, but were inversely related to plasma alpha-t ocopherol concentrations (r = -0.53, P = 0.02) and alpha-tocopherol: c holesterol + triglyceride ratios (r = -0.57, P = 0.01). These results indicate that the factors influencing the availability of retinol and alpha-tocopherol in obese children may be different.