Jy. Wang et al., CLINICOPATHOLOGICAL STUDY OF ADVANCED GASTRIC-CANCER WITHOUT SEROSAL INVASION IN YOUNG AND OLD PATIENTS, Journal of surgical oncology, 63(1), 1996, pp. 36-40
Fifty-seven patients treated by radical gastric resections were retros
pectively studied to understand the clinicopathologic characteristics
of advanced gastric cancer without serosal invasion (the depth of tumo
r invasion limited to the muscularis propria or subserosal layer) in y
oung and old age persons. There were 36 patients in the old age group
(age >60 years) and 21 in the young age group (age less than or equal
to 40 years). The clinical and pathologic parameters for this study in
cluded sex, gross type, location, maximum tumor size, depth of invasio
n, lymph node metastasis, tumor stage, histologic type, and rate of cu
rative resection. The old patients had a higher percentage of small tu
mors, subserosal invasion and lymph node metastasis, but these paramet
ers were not significantly different from those of the young patients,
nor did the sex ratio, gross type, location, and rate of curative res
ection show significant differences. The histologic feature was the on
ly statistically significant parameter, determined by univariate and m
ultivariate analyses. Poorly differentiated adenocarcinoma and signet
ring cell carcinoma were detected in 10 (47.6%) and 4 (19.0%) of the 2
1 younger patients, respectively, while there were 4 (11.1%) and 2 (5.
6%) in the old age group. Although the gastric cancer in young patient
s had more aggressive histologic characteristics than it did in elderl
y patients, survival rates between the two groups did not differ to an
y great degree. Our findings indicate that the prognosis for younger p
atients with advanced gastric cancer without serosal invasion was favo
rable when curative resection was performed. (C) 1996 Wiley-Liss, Inc.