Primary extranodal lymphoma arising from skeletal muscle is rare. We d
escribe a case of primary skeletal muscle lymphoma, diffuse large B-ce
ll type. A review of the literature showed that it mostly involves the
extremities, especially the thighs, in the elderly and has an aggress
ive histology of the B-cell immunophenotype. Different pathogenetic me
chanisms for the occurrence of malignant lymphoma in extranodal sites
are discussed.