CASE-REPORTS - DELAYED HEMOLYTIC TRANSFUSION REACTION IN SICKLE-CELL DISEASE

Citation
Sk. Syed et al., CASE-REPORTS - DELAYED HEMOLYTIC TRANSFUSION REACTION IN SICKLE-CELL DISEASE, The American journal of the medical sciences, 312(4), 1996, pp. 175-181
Citations number
51
Categorie Soggetti
Medicine, General & Internal
ISSN journal
00029629
Volume
312
Issue
4
Year of publication
1996
Pages
175 - 181
Database
ISI
SICI code
0002-9629(1996)312:4<175:C-DHTR>2.0.ZU;2-1
Abstract
This article reports the details of delayed hemolytic transfusion reac tions in four patients with sickle cell disease. These cases demonstra te the characteristics of the reactions, the significant risks involve d, and the principles useful in diagnosis and treatment. Patients with sickle cell disease are at particular risk for delayed hemolytic tran sfusion reactions because they may be transfused at intervals over man y years; they frequently form alloantibodies because of antigenic diff erences from the donor population; and they may receive emergency care in different hospitals where transfusion records are not available, I n addition, exchange transfusions, which are often used for patients w ith sickle cell disease and which were given in three of these cases, raise the risks through increased exposure to foreign erythrocyte anti gens and through an increased volume of erythrocytes susceptible to he molysis, It was concluded that the hazards of these transfusion reacti ons justify preventive measures, such as extended erythrocyte phenotyp ing of patients with sickle cell disease and extended phenotypic match ing of transfused cells.