OMEGA-CONOTOXIN-MVIID BLOCKS AN OMEGA-CONOTOXIN-GVIA-SENSITIVE, HIGH-THRESHOLD CA2-CELLS( CURRENT IN FISH RETINAL GANGLION)

Authors
TABATA T OLIVERA BM ISHIDA AT
Citation
T. Tabata et al., OMEGA-CONOTOXIN-MVIID BLOCKS AN OMEGA-CONOTOXIN-GVIA-SENSITIVE, HIGH-THRESHOLD CA2-CELLS( CURRENT IN FISH RETINAL GANGLION), Neuropharmacology, 35(5), 1996, pp. 633-636
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Neuropharmacology → ACNP
ISSN journal
00283908
Volume
35
Issue
5
Year of publication
1996
Pages
633 - 636
Database
ISI
SICI code
0028-3908(1996)35:5<633:OBAOH>2.0.ZU;2-U
Abstract
Reduction of Ca2+ current amplitude by the Conus peptide omega-conotox in-MVIID (omega-CTx-MVIID) was measured in voltage-clamped, goldfish r etinal ganglion cells. Effects of depolarizing shifts in holding poten tial, and sequential applications of omega-CTx-MVIID, omega-CTx-GVIA, and BAY-K-8644, together with effects of Ni2+ and omega-Aga-IIIA, indi cate that omega-CTx-MVIID may target Ca2+ channels differing from thos e termed T, L, N, P, Q and R. Copyright (C) 1996 Elsevier Science Ltd