Eleven patients (nine females, two males) with anaemia due to acute an
d chronic gastrointestinal blood loss were found to have gastric antra
l vascular ectasia (watermelon stomach). Nine patients were transfusio
n-dependent, receiving a mean of 13.1 units over a mean period of 12.3
months. All patients received neodymium:yttrium-aluminium-garnet lase
r coagulation with a median of 3.0 treatment sessions. Post-treatment
transfusion needs were abolished in six patients and minimal in two pa
tients during a mean follow up of 27.3 months (range 12-60 months). Ov
erall there was a mean reduction in transfusion requirement with treat
ment from 2.5 units per month to 0.4 units per month (P < 0.02). Mean
pretreatment haemoglobin improved from 7.7 to 11.9 g/dL after treatmen
t (P < 0.001). No complications occurred. Laser coagulation is safe an
d effective treatment for anaemia due to watermelon stomach and should
be considered as first line therapy.