CALCIUM-CHANNEL BLOCKERS IN PREGNANCY

Calcium channel blockers are used more and more pregnancy. No teratoge nic effect has been observed humans despite the lack of adequate studi es. The use of calcium channel blockers in premature labor and in arte rial hypertension may be recommended. In premature labor, maternal tol erance is better than that of beta adrenergic drugs. In hypertensive d isorders of pregnancy, current data indicate that calcium channel bloc kers may be a good second line medication. Acute lowering of maternal blood pressure (by sublingual or intravenous use) may however induce f etal distress.