Calcium channel blockers are used more and more pregnancy. No teratoge
nic effect has been observed humans despite the lack of adequate studi
es. The use of calcium channel blockers in premature labor and in arte
rial hypertension may be recommended. In premature labor, maternal tol
erance is better than that of beta adrenergic drugs. In hypertensive d
isorders of pregnancy, current data indicate that calcium channel bloc
kers may be a good second line medication. Acute lowering of maternal
blood pressure (by sublingual or intravenous use) may however induce f
etal distress.