LOW RESPONSIVE PATIENTS IN THE IVF PROGRA M OVER A 3 YEARS PERIOD

Our study consisted of a population of 100 women who represented an in sufficient response to the induction of ovulation. We researched to fi nd out which therapeutic approach, of the subsequent attempts to IVF w ould give greater hope to a better response. Two groups were individua lized : in the first group (62 women) we obtained at least once, 3 ooc ytes (288 attempts), in the second group (38 women) we always obtained less than 3 oocytes. In the first group, in order to raise the pregna ncy rate it was necessary to raise the rate of E(2)/oocyte. There fore raising the duration of stimulation and the quantity of ampullage of hMG. The long protocol, hMG, produced the best results. In the second group, the results were always worse if was more than a problem of pro tocol, it was a problem of the patients. In reality the future of ther apy for lower responsive patients is probably biological with hatching today and the possibilities with oocytary maturation in vitro in the near future.