CHANGES IN EEG ORDER IN NEUROLEPTICALLY TREATED NORMAL VOLUNTEERS DURING A VOLUNTARY MOVEMENT TASK

15 normal volunteers were treated over three weeks with haloperidol (H AL) and in the third week additionally with biperidene (BIP). The orde r of the EEG spectra at different topographical locations and in diffe rent frequency bands during a movement task was analyzed using uncerta inty analysis (UA), a multivariate analysis technique based on informa tion-theoretical methods. Different patterns of drug-induced changes w ere found. HAL decreases the theta and alpha band order at the fronto- central lateral areas but increases it at the fronto-central midline i n the theta band and at the parietal areas in the alpha band. With the exception of the fronto-central midline locations, BIP more or less c ounterbalances the effect of HAL. Volunteers felt unwell and had motor disturbances during HAL and felt well again during HAL+BIP. Reaction time values were increased during HAL and normalized during HAL+BIP.