PREPARATION OF HETEROCYCLIC-COMPOUNDS VIA CARBON-CARBON BOND FORMATION CATALYZED BY AN ANTIBODY

A monoclonal antibody, elicited by a transition-state analogue, acted as an enzymelike catalyst for the formation of carbon-carbon bond. The generation of carboanion by the action of abzyme and the internal nuc leophilic attack on the activated functional group, such as the carbon yl and/or the imine group with a fluoroalkyl group, producing the corr esponding delta-lactones, are described.