OPTIMIZATION OF MAGNETIZATION-TRANSFER EXPERIMENTS TO MEASURE FIRST-ORDER RATE CONSTANTS AND SPIN-LATTICE RELAXATION-TIMES

A recent analysis of the optimization of magnetization transfer experi ments to estimate first-order rate constants is extended to the design of experiments for measuring these constants and T-1 when both parame ters are initially unknown, When the number of measurement times is fi xed, an optimal design will consist of a set of measurement times whic h ensures that the precision of the estimates of the combination of k and T-1 is as small as possible in a worst-case scenario. Simple expre ssions are given for the parameters that characterize the optimal desi gn.