BERNARD-SOULIER SYNDROME - A FLOW CYTOMETRIC ANALYSIS OF MEMBRANE GP-IB EXPRESSION

Authors
YESILIPEK MA KARADOGAN I UNDAR L
Citation
Ma. Yesilipek et al., BERNARD-SOULIER SYNDROME - A FLOW CYTOMETRIC ANALYSIS OF MEMBRANE GP-IB EXPRESSION, Turkish Journal of Pediatrics, 38(3), 1996, pp. 375-379
Citations number
8
Categorie Soggetti
Pediatrics
Journal title
Turkish Journal of Pediatrics → ACNP
ISSN journal
00414301
Volume
38
Issue
3
Year of publication
1996
Pages
375 - 379
Database
ISI
SICI code
0041-4301(1996)38:3<375:BS-AFC>2.0.ZU;2-M
Abstract
A case of Bernard-Soulier syndrome In a five-year-old female is presen ted. The diagnosis was confirmed by flow cytometric analysis of glycop rotein Ib (CD 42b) in addition to the patient's classic laboratory fin dings such as prolonged bleeding time, mild thrombocytopenia, large pl atelets and failure of platelet aggregation with ristocetin. Her paren ts and sibling had normal coagulation tests and CD 42b levels. It is e mphasized that flow cytometric analysis is useful in the confirmation of congenital platelet function defects.