COGNITIVE EFFECTS OF FLUMAZENIL IN PATIENTS WITH ALZHEIMERS-DISEASE

Authors
OTT BR THOMPSON JA WHELIHAN WM
Citation
Br. Ott et al., COGNITIVE EFFECTS OF FLUMAZENIL IN PATIENTS WITH ALZHEIMERS-DISEASE, Journal of clinical psychopharmacology, 16(5), 1996, pp. 400-402
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Psychiatry,"Clinical Neurology
Journal title
Journal of clinical psychopharmacology → ACNP
ISSN journal
02710749
Volume
16
Issue
5
Year of publication
1996
Pages
400 - 402
Database
ISI
SICI code
0271-0749(1996)16:5<400:CEOFIP>2.0.ZU;2-S
Abstract
Intravenous flumazenil mas administered to two patients with probable Alzheimer's disease. Neuropsychological tests were administered at bas eline, immediately after drug administration, and at washout 3 hours l ater, Cognitive function was observed to decline in both patients with eventual return to baseline, which indicates an adverse effect of flu mazenil. Tests of vigilance were most severely affected, which, may ha ve been related to an inverse agonistic effect of flumazenil in produc ing symptoms of anxiety.