IDENTIFICATION OF CYCLIC CYSTATHIONINE SULFOXIDE AND N-ACETYLCYCLIC CYSTATHIONINE IN THE URINE OF A PATIENT WITH CYSTATHIONINURIA USING LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY WITH AN ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION INTERFACE SYSTEM

Authors
ZHANG JY SUGAHARA K SAGARA Y HASHIMOTO K MASUOKA N KODAMA H
Citation
Jy. Zhang et al., IDENTIFICATION OF CYCLIC CYSTATHIONINE SULFOXIDE AND N-ACETYLCYCLIC CYSTATHIONINE IN THE URINE OF A PATIENT WITH CYSTATHIONINURIA USING LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY WITH AN ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION INTERFACE SYSTEM, Metabolism, clinical and experimental, 45(10), 1996, pp. 1312-1316
Citations number
14
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Metabolism, clinical and experimental → ACNP
ISSN journal
00260495
Volume
45
Issue
10
Year of publication
1996
Pages
1312 - 1316
Database
ISI
SICI code
0026-0495(1996)45:10<1312:IOCCSA>2.0.ZU;2-N
Abstract
Perhydro-1,4-thiazepine-4,5-dicarboxylic acid sulfoxide (cyclic cystat hionine sulfoxide [cyclic cystaSO]) and N-acetylperhydro-1,4-thiazepin e-3,5-dicarboxylic acid (NAc-cyclic cysta) have been identified in the urine of a patient with cystathioninuria as new metabolites of cystat hionine for the first time using liquid chromatography-mass spectromet ry with an atmospheric pressure chemical ionization interface system ( LC/APCI-MS). The concentrations of cyclic cystaSO and NAc cyclic cysta in the urine of a patient with cystathioninuria have also been determ ined for the first time using this method: 18.24 +/- 0.79 and 25.23 +/ - 0.83 mg/g creatinine, respectively. Copyright (C) 1996 by W.B. Saund ers Company