NONSTEROIDAL ANTIINFLAMMATORY DRUG-USE AND COGNITIVE FUNCTION IN THE ELDERLY - INCONCLUSIVE RESULTS FROM A POPULATION-BASED COHORT STUDY

As part of the cohort Paquid, we studied the relationship between the use of NSAID, incidence of dementia, and evolution of cognitive functi ons. Dementia was diagnosed by DSM III criteria and cognitive function s was assessed through the Mini-Mental Status Examination (MMSE). Duri ng 2 years of follow up, the incidence rate of dementia was 3.84% amon g 53 NSAID users as compared with 3.77% in 1199 nonusers (OR, 0.98; 95 % CI, 0.23-4.16). Using a cutoff of -3 points for the MMSE score and t aking into account age and educational status in a logistic regression model, NSAID use was related to an unfavorable variation of the MMSE score (OR, 2.84; 95% CI, 0.99-8.1).