AROMATIC HYDROGEN-BOND IN SEQUENCE-SPECIFIC PROTEIN-DNA RECOGNITION

Authors
PARKINSON G GUNASEKERA A VOJTECHOVSKY J ZHANG XP KUNKEL TA BERMAN H EBRIGHT RH
Citation
G. Parkinson et al., AROMATIC HYDROGEN-BOND IN SEQUENCE-SPECIFIC PROTEIN-DNA RECOGNITION, Nature structural biology, 3(10), 1996, pp. 837-841
Citations number
28
Categorie Soggetti
Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
3
Issue
10
Year of publication
1996
Pages
837 - 841
Database
ISI
SICI code
1072-8368(1996)3:10<837:AHISPR>2.0.ZU;2-6
Abstract
An aromatic hydrogen bond-an interaction between the pi-electron cloud of an aromatic ring and a hydrogen-bond donor-can substitute for a co nventional hydrogen bond in sequence-specific protein-DNA interactions and can contribute 0.5-1 kcal mol(-1) to binding and 1-2 kcal mol(-1) to specificity.