LIQUID AND SUBCRITICAL CO2 SEPARATIONS OF ENANTIOMERS ON A BROADLY APPLICABLE POLYSILOXANE CHIRAL STATIONARY-PHASE

Incorporation of chiral selector 1 into a polysiloxane which is then i mmobilized on silica affords a chiral stationary phase (CSP 1) capable of resolving a broad array of enantiomers by either high-performance liquid chromatography or supercritical fluid chromatography (SFC). Lik e its brush-type analog, the commercial version of which is known as t he Whelk-O 1, CSP 1, the ''polyWhelk-O'', is stable to normal and reve rsed-phase conditions and to a wide range of temperatures, mobile phas es and additives. In most cases, the polyWhelk-O affords greater enant ioselectivity and less retention than does the brush-type Whelk-O 1 un der the same conditions. An extensive collection of separations of the enantiomers of a variety of types of compounds is presented to illust rate the scope and level of performance typically afforded by the poly Whelk-O columns.