LOCALIZATION OF MESSENGER-RNA FOR LEUKEMIA INHIBITORY FACTOR-RECEPTORIN THE ADULT-RAT BRAIN

The distribution of leukemia inhibitory factor receptor (LIFR) mRNA in the adult rat brain was examined by in situ hybridization technique. The intense signals of LIFR mRNA were restricted to specific brain reg ions relevant to the motor and sensory systems. The moderate expressio n of LIFR mRNA was observed in several brain regions, including the ce rebral cortex, hippocampus, thalamus, hypothalamus and cerebellum. Mos t of the signals of LIFR mRNA were detected on likely neuronal cells. These findings suggest the possibility that LIF has potential actions on the neuronal cells in the central nervous system of the adult rat.