Regulating metals on the basis of simple measures of bioaccumulation i
n aquatic organisms gives misleading results. Simple bioaccumulation f
actors are useful in characterizing the hazard posed by hydrophobic or
ganic compounds, but the bioaccumulation of metals is more complex. Fo
r metals that are essential for health, many organisms have the abilit
y to control and maintain internal metal concentrations in the presenc
e of significant variations in external concentrations. Hence bioaccum
ulation factors expressed as the ratio of wet tissue concentration and
water concentration must vary according to external concentration. Re
gulations that specify a single generic accumulation factor are thus i
nappropriate.