ORAL-ADMINISTRATION OF BOVINE LACTOFERRIN FOR TREATMENT OF INTRACTABLE STOMATITIS IN FELINE IMMUNODEFICIENCY VIRUS (FIV)-POSITIVE AND FIV-NEGATIVE CATS
R. Sato et al., ORAL-ADMINISTRATION OF BOVINE LACTOFERRIN FOR TREATMENT OF INTRACTABLE STOMATITIS IN FELINE IMMUNODEFICIENCY VIRUS (FIV)-POSITIVE AND FIV-NEGATIVE CATS, American journal of veterinary research, 57(10), 1996, pp. 1443-1446
Objective-To study the effects of oral administration of bovine lactof
errin (LF) on intractable stomatitis in feline immunodeficiency virus
(FIV)-positive and FIV-negative cats, and phagocytosis of neutrophils
in healthy and ill cats, simultaneously. Animals-7 ill cats with diagn
osis of intractable stomatitis (4 FIV positive and 3 FIV negative) and
7 healthy, FIV-negative cats. Procedure-LF (40 mg/kg of body weight)
was applied topically to the oral mucosa of cats with intractable stom
atitis daily for 14 days and improvement of clinical signs of disease
(pain-related response, salivation, appetite, and oral inflammation),
expressed by scoring from 1 to 4, were evaluated, Assay of neutrophil
phagocytosis was examined before and 2 weeks after starting LF treatme
nt, using nonopsonized hydrophilic polymer particles (2 mu m). Results
-Oral administration of LF improved intractable stomatitis in all 4 re
spects. Phagocytic activity of neutrophils increased after LF treatmen
t. This effect was observed in healthy and ill (FIV positive and FIV n
egative) cats. Conclusion and Clinical Relevance-Oral administration o
f if improved intractable stomatitis and concurrently enhanced the hos
t defense system. Topical application of if to oral mucous membrane is
useful as a treatment for intractable stomatitis even in FIV-positive
cats.