Am. Molinspujol et al., SYNTHESIS AND NUCLEOPHILIC PROPERTIES OF 1,2-DIALKYL-3-NITROPYRROLES AND 1,5-DIALKYL-4-NITROPYRROLE-2-CARBOXYLIC ACID-DERIVATIVES, Journal of the Chemical Society. Perkin transactions. I, (18), 1996, pp. 2277-2289
1,2-Dialkyl-3-nitropyrroles 1 are versatile synthetic tools for obtain
ing substituted pyrrolidines or fused ring heterocycles such as pyrrol
opyridines, pyrrolopyrimidines or pyrroloazepines. We have established
a method for obtaining compounds related to structure 1 and studied t
he reactivity as a nucleophile of the benzylic type moiety in the alky
l residue bound to position 2.