Jc. Rajapakse et al., REGIONAL MRI MEASUREMENTS OF THE CORPUS-CALLOSUM - A METHODOLOGICAL AND DEVELOPMENTAL-STUDY, Brain & development, 18(5), 1996, pp. 379-388
A technique for quantifying the midsagittal size and shape of the corp
us callosum (CC) from magnetic resonance brain scans is presented. The
technique utilizes the distances to the ventral and dorsal boundaries
of small sectors of the CC from a reference point to compute the size
and shape parameters of the CC and its subdivisions, Intrarater and i
nterrater interclass correlation coefficients for the area measurement
s ranged from 0.88 to 0.99. Correlations between these automated measu
res and those obtained by pixel counting were equally high, The corpus
callosa of 104 (57 male and 47 female) right-handed healthy children
and adolescents, ages 4-18, were examined in relation to age and sex,
Corpus callosum growth was most striking for the splenium and isthmus
with some changes in the midbody regions, The area and perimeter of th
ese regions increased, shapes became more compact, and the boundaries
became more regular with age. The length and curvature at the anterior
and posterior regions of the CC increased more rapidly in males than
in females, These significant and consistent results indicate that the
method is reliable and sensitive to developmental changes of the CC.