E. Ovrum et al., HEPARINIZED CARDIOPULMONARY BYPASS AND FULL HEPARIN DOSE MARGINALLY IMPROVE CLINICAL-PERFORMANCE, The Annals of thoracic surgery, 62(4), 1996, pp. 1128-1133
Background. The use of completely heparin coated cardiopulmonary bypas
s circuits in combination with a reduced systemic heparin dose has pre
viously been shown to reduce postoperative bleeding after cardiac oper
ations. However, it has remained unknown whether this effect was relat
ed to the improved biocompatibility of the heparin-treated surfaces pe
r se or to the reduced exposure to circulating heparin. Therefore we i
nvestigated patients undergoing heparin-coated extracorporeal circulat
ion and full systemic heparinization. Methods. Two hundred seventeen p
atients having first-time myocardial revascularization were prospectiv
ely randomized either to a group in which a completely (''tip-to-tip''
) heparin-coated circuit (Duraflo II) was used for perfusion (n = 107)
or to a control group (n = 110) in which an uncoated, but otherwise i
dentical, circuit was used. Full systemic heparinization was induced i
n both groups (activated clotting time, >480 seconds). The postoperati
ve blood loss, requirements for homologous blood transfusions, clinica
l performance, and complications were recorded. Results. The amount of
postoperative mediastinal drainage was nearly identical in the two gr
oups. The mean 18-hour drainage was 694 +/- 313 mL in the heparin-coat
ed group and 679 +/- 269 mL in the control group (p = not significant)
. Three patients in the heparin-coated group and 6 patients in the con
trol group received homologous red blood cell transfusions (p = not si
gnificant). The incidence of postoperative atrial fibrillation was sig
nificantly lower in the heparin-coated group (21.8%) than in the contr
ol group (43.1%) (p = 0.002). Otherwise, there were no significant dif
ferences in the extubation times, the incidence of perioperative myoca
rdial infarction, the creatinine concentration, the incidence of neuro
logic dysfunction, the progress in physical rehabilitation, or the hem
oglobin concentration at discharge. Conclusions. The use of completely
heparin coated cardiopulmonary bypass circuits and full systemic hepa
rinization in patients undergoing coronary artery bypass procedures di
d not reduce postoperative bleeding or change clinical performance, ex
cept for a significant decrease in the incidence of postoperative atri
al fibrillation.