SPECTROPHOTOMETRIC DETERMINATION OF ACRIVASTINE IN URINE AND CAPSULES

Three sensitive and accurate spectrophotometric methods are presented for the determination of the antihistaminic acrivastine (ACR) in capsu les and urine. The first method utilizes the reaction of 2-nitrophenyl hydrazine hydrochloride in presence of dicyclohexylcarbodiimide and py ridine. The violet colour of the resulting acid hydrazide is measured at 550 nm. The second method is based on alkaline oxidation of the dru g with potassium permanganate and subsequent measurement of the formed manganate ion at 608 nm. The third method uses derivative spectrophot ometry for the determination of ACR. The last method is extended to th e in vitro determination of the drug in urine. All methods gave a rela tive standard deviation of less than 2%.