Force microscopy has been used to machine nanocrystals of MoO3 and man
ipulate the resulting objects into new nanostructures. MoO3 nanocrysta
ls were grown on the surfaces of MoS2 single crystals by controlled th
ermal oxidation. These nanocrystals may be moved and modified with a f
orce microscope by controlling the applied load. The atomic structure
of the nanocrystal-substrate interface is shown to constrain the motio
n of the nanocrystals to the lattice rows of the substrate, a phenomen
on termed lattice-directed sliding. In addition, scanning in a directi
on off this preferred sliding direction can be used to machine the MoO
3 thus making it possible to selectively move and modify these nanocry
stals. Significantly, our ability to machine and manipulate the nanocr
ystals has been exploited to fabricate interlocking nanostructures tha
t can be reversibly assembled and disassembled.