A DISTINCT SYNDROME OF FAMILIAL CLEFT-LIP AND PALATE WITH PROMINENT EYES AND CHARACTERISTIC FACIES IN 2 UNRELATED FAMILIES

A variable degree of facial and oral clefting segregating with the cha racteristic facies, wide set prominent eyes, a broad nasal tip, and pr otruding external ears is described in several individuals spread over four generations in a British family and over two generations in a Sp anish family. None of the affected individuals have any other developm ental anomaly. The occurrence of oral and facial clefting associated w ith prominent eyes and characteristic facies probably indicates the ex istence of a distinct autosomal dominant syndrome.