A DISTINCT SYNDROME OF FAMILIAL CLEFT-LIP AND PALATE WITH PROMINENT EYES AND CHARACTERISTIC FACIES IN 2 UNRELATED FAMILIES

Citation
D. Kumar et al., A DISTINCT SYNDROME OF FAMILIAL CLEFT-LIP AND PALATE WITH PROMINENT EYES AND CHARACTERISTIC FACIES IN 2 UNRELATED FAMILIES, Clinical dysmorphology, 5(4), 1996, pp. 295-301
Citations number
6
Categorie Soggetti
Genetics & Heredity
Journal title
ISSN journal
09628827
Volume
5
Issue
4
Year of publication
1996
Pages
295 - 301
Database
ISI
SICI code
0962-8827(1996)5:4<295:ADSOFC>2.0.ZU;2-S
Abstract
A variable degree of facial and oral clefting segregating with the cha racteristic facies, wide set prominent eyes, a broad nasal tip, and pr otruding external ears is described in several individuals spread over four generations in a British family and over two generations in a Sp anish family. None of the affected individuals have any other developm ental anomaly. The occurrence of oral and facial clefting associated w ith prominent eyes and characteristic facies probably indicates the ex istence of a distinct autosomal dominant syndrome.