We study the effective potential U-e between a rough self-affine surfa
ce, and a membrane bounded by this surface. We find that the effect of
the substrate roughness exponent H on U-e is significant for zeta<xi.
zeta is a healing length, and xi the in-plane roughness correlation le
ngth. However, the effect of H is negligible for membrane-surface sepa
rations larger than a characteristic membrane-surface separation tau.
Moreover. the roughness contribution to U-e scales as similar to zeta(
2H) for zeta<xi, and as similar to zeta(-4) for zeta much greater than
xi.