TICL4 MEDIATED LIBH4 REDUCTION OF BETA-KETOPHOSPHINE OXIDES - A HIGH STEREOSELECTIVE ROUTE TO THE SYNTHESIS OF ANTI-BETA-HYDROXYPHOSPHINE OXIDES

Authors
BARTOLI G BOSCO M SAMBRI L MARCANTONI E
Citation
G. Bartoli et al., TICL4 MEDIATED LIBH4 REDUCTION OF BETA-KETOPHOSPHINE OXIDES - A HIGH STEREOSELECTIVE ROUTE TO THE SYNTHESIS OF ANTI-BETA-HYDROXYPHOSPHINE OXIDES, Tetrahedron letters, 37(41), 1996, pp. 7421-7424
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
41
Year of publication
1996
Pages
7421 - 7424
Database
ISI
SICI code
0040-4039(1996)37:41<7421:TMLROB>2.0.ZU;2-Z
Abstract
The reduction of an alpha-alkyl-beta-kerophosphine oxide with LiBH4 in presence of a strong chelating agent, such as TiCl4, gives the corres ponding beta-hydroxyphosphine oxide in high yields and with high anti- diastereoselectivity independently from the size of both the alpha- an d beta-alkyl chains. Copyright (C) 1996 Elsevier Science Ltd