HIGHLY STEREOSELECTIVE HYDROXY-ALKYLATION, SILYLATION AND ALKYLATION REACTIONS OF LITHIUM DERIVATIVES OF CHIRAL PHOSPHINE OXIDES

Authors
GUEGUEN C MITCHELL HJ OBRIEN P WARREN S
Citation
C. Gueguen et al., HIGHLY STEREOSELECTIVE HYDROXY-ALKYLATION, SILYLATION AND ALKYLATION REACTIONS OF LITHIUM DERIVATIVES OF CHIRAL PHOSPHINE OXIDES, Tetrahedron letters, 37(41), 1996, pp. 7461-7464
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
41
Year of publication
1996
Pages
7461 - 7464
Database
ISI
SICI code
0040-4039(1996)37:41<7461:HSHSAA>2.0.ZU;2-Z
Abstract
Reactions of lithium derivatives of chiral phosphine oxides with keton es (e.g cyclobutanone, valerophenone) and Me(3)SiCl proceed with excel lent levels of syn selectivity. In contrast, reactions with methyl iod ide are moderately anti selective and those with aldehydes show no sel ectivity whatsoever. Copyright (C) 1996 Elsevier Science Ltd