SYNTHESIS, CONFORMATION AND BIOLOGICAL PROPERTIES OF 2',3'-DIDEOXY-3'-FLUORO-5-CHLORO-4-THIOURIDINE POTENTIAL ANTI-HIV AGENT

Authors
POOPEIKO NE DRABIKOWSKA AK POZNANSKI J SHUGAR D KULIKOWSKI T
Citation
Ne. Poopeiko et al., SYNTHESIS, CONFORMATION AND BIOLOGICAL PROPERTIES OF 2',3'-DIDEOXY-3'-FLUORO-5-CHLORO-4-THIOURIDINE POTENTIAL ANTI-HIV AGENT, Collection of Czechoslovak Chemical Communications, 61, 1996, pp. 16-19
Citations number
12
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
61
Year of publication
1996
Pages
16 - 19
Database
ISI
SICI code
0010-0765(1996)61:<16:SCABPO>2.0.ZU;2-4
Abstract
Regioselective synthesis of 2',3'-dideoxy-3'-fluoro-5-chloro-4-thiouri dine, a potential anti retroviral agent, via sequential modification o f the sugar moiety and the base of 2',5'-di-O-benzoyl-3'-deoxy-3'-fluo rouridine, is described. Solution conformations, and interactions with thymidine phosphorylase. of several 2',3'-dideoxy-3'-fluoronucleoside s are also reponed.