HYDROLYSIS AND METHANOLYSIS OF THE PHENYL ESTER OF THYMIDINE 3',5'-CYCLIC-MONOPHOSPHATE - PH-DEPENDENT COMPETITION BETWEEN PO AND CO BOND RUPTURES

Authors
OIVANEN M VARILA J HANKAMAKI T KOOLE LH LONNBERG H
Citation
M. Oivanen et al., HYDROLYSIS AND METHANOLYSIS OF THE PHENYL ESTER OF THYMIDINE 3',5'-CYCLIC-MONOPHOSPHATE - PH-DEPENDENT COMPETITION BETWEEN PO AND CO BOND RUPTURES, Collection of Czechoslovak Chemical Communications, 61, 1996, pp. 26-29
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
61
Year of publication
1996
Pages
26 - 29
Database
ISI
SICI code
0010-0765(1996)61:<26:HAMOTP>2.0.ZU;2-Y
Abstract
pH-Rate profiles and product distributions for the hydrolytic reaction s of the cis-phenyl ester of thymidine 3',5'-cyclic monophosphate have been determined over the pH-range 0-14. The pH-independent hydrolysis (pH 2-7) of the phosphotriester moiety appears to proceed mainly by c leavage of the C5'O bund, whereas the hydroxide- and hydronium-ion-cat alyzed reactions involve rupture of one of the PO bonds.