ZN2+ PROMOTED HYDROLYSIS OF OLIGONUCLEOTIDES

Authors
KUUSELA S GUZAEV A LONNBERG H
Citation
S. Kuusela et al., ZN2+ PROMOTED HYDROLYSIS OF OLIGONUCLEOTIDES, Collection of Czechoslovak Chemical Communications, 61, 1996, pp. 30-32
Citations number
6
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
61
Year of publication
1996
Pages
30 - 32
Database
ISI
SICI code
0010-0765(1996)61:<30:ZPHOO>2.0.ZU;2-H
Abstract
The Zn2+ promoted hydrolysis of short oligonucleotides has been studie d. The results obtained show that thr presence of an adjacent phosphat e group enhances the metal ion promoted hydrolysis of phosphodiester b onds. The effect of dianionic monophosphate groups is 10-fold larger t han that of monoanionic phosphodiester bond. The mechanism of the rate -enhancement will be discussed.