SYNTHESIS OF AN AZA-ANALOG OF S-ADENOSYL-L-METHIONINE AND ITS BINDINGTO THE ESCHERICHIA-COLI METHIONINE REPRESSOR PROTEIN (METJ)

Authors
THOMPSON MJ MEKHALFIA A JAKEMAN DL PHILLIPS SEV PHILLIPS K PORTER J BLACKBURN GM
Citation
Mj. Thompson et al., SYNTHESIS OF AN AZA-ANALOG OF S-ADENOSYL-L-METHIONINE AND ITS BINDINGTO THE ESCHERICHIA-COLI METHIONINE REPRESSOR PROTEIN (METJ), Collection of Czechoslovak Chemical Communications, 61, 1996, pp. 85-87
Citations number
7
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
61
Year of publication
1996
Pages
85 - 87
Database
ISI
SICI code
0010-0765(1996)61:<85:SOAAOS>2.0.ZU;2-E
Abstract
Synthesis of ino-3-carboxypropyl]methylamino]-5'-deoxyadenosine is des cribed from D-adenosine and (S)-glutamic acid. This product, AzaAdoMet 2, has a pK(a) of 7.10 for the tertiary amino group and so acts as a charge-switchable analogue of AdoMet 1. The binding of both 1 and 2 to the E. coli methionine repressor protein has been investigated by X-r ay crystallography.