INTERMOLECULAR AND INTRAMOLECULAR STACKING OF MESSENGER-RNA CAP-ANALOGS - RELEVANCE TO INITIATION OF TRANSLATION

Authors
STOLARSKI R ZDANOWSKI K CHLEBICKA L WIECZOREK Z SITEK A STEPINSKI J JANKOWSKA M MATTINEN J TEMERIUSZ A DARZYNKIEWICZ E
Citation
R. Stolarski et al., INTERMOLECULAR AND INTRAMOLECULAR STACKING OF MESSENGER-RNA CAP-ANALOGS - RELEVANCE TO INITIATION OF TRANSLATION, Collection of Czechoslovak Chemical Communications, 61, 1996, pp. 217-221
Citations number
5
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
61
Year of publication
1996
Pages
217 - 221
Database
ISI
SICI code
0010-0765(1996)61:<217:IAISOM>2.0.ZU;2-A
Abstract
Self-association of a series of newly synthesized dinucleotide mRNA ca p-analogues has been investigated in aqueous buffers by means of H-1 N MR and fluorescence, and compared with that for a regular cap, 7-methy lguanosine(5')ppp(5')guanosine (m(7)GpppG). The previously investigate d inter-molecular association between the tripeptide, Trp-Leu-Glu, and cap analogues (Biochim. Biophys. Acta 1293, 97 (1996)) has been exten ded to include m(7)GpppC and m(7)Gpppm(7)G. More detailed insight into the stacking interactions was attempted by means of molecular dynamic s simulations.